https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Effects of prenatal stress on fetal neurodevelopment and responses to maternal neurosteroid treatment in guinea pigs https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16551 Wed 11 Apr 2018 17:05:24 AEST ]]> Maternal stress in pregnancy affects myelination and neurosteroid regulatory pathways in the guinea pig cerebellum https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33789 Tue 15 Jan 2019 12:58:06 AEDT ]]> Loss of neurosteroid-mediated protection following stress during fetal life https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24307 A receptor subunits that normally heighten neurosteroid sensitivity. These stressors also result in altered placental allopregnanolone metabolism pathways. These findings suggest that reduced neurosteroid production and action in the perinatal period may contribute to some of the adverse neurodevelopmental and behavioural outcomes that result from these pregnancy compromises. Studies examining perinatal steroid supplementation therapy with non-metabolisable neurosteroid analogues to improve these outcomes are warranted.]]> Thu 21 Oct 2021 12:51:39 AEDT ]]> Models of perinatal compromises in the guinea pig: their use in showing the role of neurosteroids in pregnancy and the newborn https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29502 Sat 24 Mar 2018 07:29:45 AEDT ]]> Prenatal stress alters hippocampal neuroglia and increases anxiety in childhood https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26441 A receptor subunit expression was also assessed using RT-PCR. Neonates born from mothers stressed during late pregnancy showed a reduction in both MBP (p < 0.01) and GFAP (p < 0.05) expression in the CA1 region of the hippocampus at 21 days of age. Pups of prenatally stressed pregnancies also showed higher levels of anxiety and neophobic behaviours at the equivalent of childhood (p < 0.05). There were no significant changes observed in allopregnanolone levels, 5αR1/2 expression, or GABAA receptor subunit expression in prenatally stressed neonates compared to controls. This study shows alterations in markers of myelination and reactive astrocytes in the hippocampus of offspring exposed to prenatal stress. These changes are also observed in offspring that show increased anxiety behaviours at the equivalent of childhood, which indicates ongoing structural and functional postnatal changes after prenatal stress exposure.]]> Sat 24 Mar 2018 07:27:17 AEDT ]]> Severity and timing: how prenatal stress exposure affects glial developmental, emotional behavioural and plasma neurosteroid responses in guinea pig offspring https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24848 Sat 24 Mar 2018 07:11:25 AEDT ]]>